Simocyclinone D8
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines[1].
Product Specifications
CAS Number
301845-97-6
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/simocyclinone-d8.html
Smiles
O[C@@]12[C@@]34[C@@]([C@@H](C5=C(O)C([C@H]6C[C@H]([C@H](OC(C)=O)[C@@H](C)O6)OC(/C=C/C=C/C=C/C=C/C(NC7=C(C8=CC=C(O)C(Cl)=C8OC7=O)O)=O)=O)=CC=C5C4=O)O)([C@@H](O)C[C@@]1(CC(C)=CC2=O)O)O3
Molecular Formula
C46H42ClNO18
Molecular Weight
932.27
References & Citations
[1]Schimana, et al. Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 I. taxonomy, fermentation, isolation and biological activities. The Journal of antibiotics 53.8 (2000) : 779-787.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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