Aristolactam A IIIa
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF) . Aristolactam A IIIa has strong cytotoxic effect on HeLa cells[1].
Product Specifications
CAS Number
97399-91-2
Product Name Alternative
Aristololactam A IIIa; Sch 546909
UNSPSC
12352005
Target
DYRK
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aristolactam-a-iiia.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC(O)=C4)=C2
Molecular Formula
C16H11NO4
Molecular Weight
281.26
References & Citations
[1]Chia YC, et al. Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod. 2000 Aug;63 (8) :1160-3.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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