What is the catalog number for Ruxolitinib (free base)?

The catalog number for Ruxolitinib (free base) is 10-042.

What sizes are available for Ruxolitinib (free base)?

Ruxolitinib (free base) is available in the following size(s): 25 mg.

Is Ruxolitinib (free base) in stock?

Ruxolitinib (free base) is currently made to order / not held in immediate stock. Contact us for lead time.

Ruxolitinib (free base)

Product Specifications

Background

Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM) . Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19) .

CAS Number

941678-49-5

Type

Chemical

Purity

Greater than or equal to 98% (HPLC)

Shipping Conditions

Room Temp

Storage Conditions

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.