Famotidine
Product Specifications
Background
Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex) . Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively) . Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) . Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.
Type
Chemical
Purity
Greater than or equal to 98% (HPLC)
Shipping Conditions
Room Temp
Storage Conditions
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=10-026
Calculated Molecular Weight
337.5
Other Product Names
MK-208; YM-11170; Pepcid; N′- (Aminosulfonyl) -3- ([2- (diaminomethyleneamino) -4-thiazolyl]methylthio) propanamidine
Physical Properties
Lyophilized
CAS Number
76824-35-6
Curated Selection
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