Alzheimers Disease gamma-Secretase Detection Set
Product Specifications
Background
For images please see PDF data sheet
Reactivity
Human
Immunogen
Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
Clonality
Polyclonal
Type
Detection Sets
Purification
Antibodies are supplied as affinity chromatography purified IgG.
Concentration
Antibody 1 mg/mL
Buffer
PBS containing 0.02% sodium azide.
Shipping Conditions
Blue Ice
Storage Conditions
Stable at 4˚ C for three months, store at -20˚ C for up to one year.
Applications Notes
These polyclonal antibodies can be used for detection of APH1, nicastrin, PEN2 and presenilin1 by immunoblot at 0.5 - 4 μ g/mL, and Immunoflourescence.
Background Reference 01
Vassar R, Bennett BD, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286:735-41.
Background Reference 02
Sinha S, Anderson JP, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999; 402:537-40.
Background Reference 03
Selkoe DJ. The cell biology of b-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 1998; 8:447-53.
Background Reference 04
Goutte C, Tsunozaki M, Hale VA, et al. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA 2002; 99:775-9.
Tested Applications
WB, IF
Physical Properties
Liquid
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