2-O-Acetyl-20-hydroxyecdysone

2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42) -induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils[1].

Product Specifications

CAS Number

[19536-25-5]

Product Name Alternative

20-Hydroxyeedysone 2-acetate

UNSPSC

12352211

Target

Amyloid-β

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-o-acetyl-20-hydroxyecdysone.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@](C(C=C3[C@]2([H])CC[C@@]4(C)[C@@]3(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])C[C@@H](O)[C@@H](OC(C)=O)C1

Molecular Formula

C29H46O8

Molecular Weight

522.67

References & Citations

[1]Yang SG, et al. Diverse ecdysterones show different effects on amyloid-β42 aggregation but all uniformly inhibit amyloid-β42-induced cytotoxicity. J Alzheimers Dis. 2010;22 (1) :107-17.