Tivozanib (hydrate)

Tivozanib hydrate (AV-951 hydrate; KRN951 hydrate) is the hydrate form of Tivozanib (HY-10977) . Tivozanib hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR) -1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrate exhibits antitumor efficacy[1].

Product Specifications

CAS Number

[682745-40-0]

Product Name Alternative

AV-951 (hydrate) ; KRN951 (hydrate)

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tivozanib-hydrate.html

Purity

99.0

Solubility

DMF : 30 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4.O

Molecular Formula

C22H21ClN4O6

Molecular Weight

472.88

References & Citations

[1]Nakamura K, et al., KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66 (18) :9134-42.