PROTAC TBL1X degrader-1
PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191) ; Black: linker (HY-168193) ; Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547) ) [1]
Product Specifications
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-tbl1x-degrader-1.html
Smiles
O=S(C1=CC=C2C(/C(C(C=C(S(N3CC(C)CC(C)C3)(=O)=O)C=C4)=C4/C2=N\OCCCNC(CCCCNC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)=N/O)=C1)(N8CC(C)CC(C)C8)=O
Molecular Formula
C49H60N8O11S2
Molecular Weight
1001.18
References & Citations
[1]Yang R, et al., Design, Synthesis, and Biological Evaluation of Selective TBL1X Degraders. ACS Med Chem Lett. 2024 Oct 1;15 (10) :1699-1707.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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