Hongotoxin-1
Hongotoxin-1, isolated from venom of Centruroides limbatus, is the inhibitor of potassium channel, with IC50 for Kv1.1, Kv1.2, Kv1.3, and Kv1.6 of 31 pM, 170 pM, 86 pM, and 6000 pM, respectively[1].
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hongotoxin-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC1=O)C(N[C@@H](CC(C)C)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC7=CC=C(C=C7)O)C(N8[C@@H](CCC8)C(N[C@@H](CC9=CNC=N9)C(O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC%10=CC=CC=C%10)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Molecular Formula
C181H299N53O49S7
Molecular Weight
4226.13
References & Citations
[1]Koschak A, et al. Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. The Journal of Biological Chemistry. 273 (5) : 2639–44.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel
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