5-HT7R antagonist 3
5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A) and 5786 nM (5-HT2A), respectively. 5-HT7R antagonist 3 possesses antidepressant and anxiolytic effects in mice[1].
Product Specifications
CAS Number
1887043-58-4
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht7r-antagonist-3.html
Smiles
O=C1N(C[C@H](O)CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C([C@](C)(C5=CC=C(F)C=C5)N1)=O
Molecular Formula
C30H33FN4O3
Molecular Weight
516.61
References & Citations
[1]Kucwaj-Brysz K, et al. The Importance of Stereochemistry in 5-HT7R Modulation─A Case Study of Hydantoin Derivatives. ACS Chem Neurosci. 2024;15 (21) :3884-3900.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT7 Receptor; D2 Receptor; mLAG-3; MUC3; α-1 microglobulin
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