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Zotepine (Standard)

Zotepine (Standard) is the analytical standard of Zotepine. This product is intended for research and analytical applications. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].

Product Specifications

CAS Number

26615-21-4

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zotepine-standard.html

Smiles

ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1

Molecular Formula

C18H18ClNOS

Molecular Weight

331.86

References & Citations

[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68 (1) :29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157 (4) :656-65.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT2 Receptor

Available Sizes

Frequently Asked Questions

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