TP-024
TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM[1]. TP-024 has antipsychotic and procognitive properties[2].
Product Specifications
CAS Number
1358575-02-6
Product Name Alternative
FTBMT
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GPR52
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-024.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C
Molecular Formula
C19H16F4N4O
Molecular Weight
392.35
Precautions
H315, H319, H335
References & Citations
[1]Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25 (12) :3098-3115.|[2]Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363 (2) :253-264.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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