TP-024

TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM[1]. TP-024 has antipsychotic and procognitive properties[2].

Product Specifications

CAS Number

[1358575-02-6]

Product Name Alternative

FTBMT

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GPR52

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tp-024.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C

Molecular Formula

C19H16F4N4O

Molecular Weight

392.35

Precautions

H315, H319, H335

References & Citations

[1]Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25 (12) :3098-3115.|[2]Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363 (2) :253-264.