I-191
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].
Product Specifications
CAS Number
[1690172-25-8]
Product Name Alternative
SX 810,(Rac)-RP-55788
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/i-191.html
Concentration
10mM
Purity
99.14
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C
Molecular Formula
C23H26FN5O2
Molecular Weight
423.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364 (2) :246-257.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Available Sizes
Curated Selection
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