Tolmesoxide

Tolmesoxide (RX71107) is a peripheral vascular dilator with blood pressure lowering activity. Tolmesoxide has shown direct vasodilation in the human forearm arterial bed and dorsal hand vein. Tolmesoxide can dose-dependently increase blood flow in the forearm and produce dilation during contraction of the dorsal hand veins. Tolmesoxide can be used to study high blood pressure and angina[1].

Product Specifications

CAS Number

[38452-29-8]

Product Name Alternative

RX71107

UNSPSC

12352005

Target

Adrenergic Receptor; Angiotensin Receptor; Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tolmesoxide.html

Smiles

CS(C1=C(C=C(OC)C(OC)=C1)C)=O

Molecular Formula

C10H14O3S

Molecular Weight

214.28

References & Citations

[1]Collier J G, et al. Comparison of effects of tolmesoxide (RX71107), diazoxide, hydrallazine, prazosin, glyceryl trinitrate and sodium nitroprusside on forearm arteries and dorsal hand veins of man[J]. British journal of clinical pharmacology, 1978, 5 (1) : 35.