MLT-943
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar IC50 across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood) . MLT-943 has anti-inflammatory activities and can be used for FcgR-mediated inflammation research[1].
Product Specifications
CAS Number
1832576-04-1
UNSPSC
12352005
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mlt-943.html
Purity
99.77
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CO[C@H](C1=C(NC(NC2=CC=NC(C(F)(F)F)=C2)=O)C=NC3=CC(Cl)=NN13)C
Molecular Formula
C16H14ClF3N6O2
Molecular Weight
414.77
References & Citations
[1]Kea Martin, et al. Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology. Front Immunol|[2]Jean Quancard, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63 (23) :14594-14608.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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