AMXT-1501
AMXT1501 is a novel inhibitor of the polyamine transport system. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1].
Product Specifications
CAS Number
[441022-64-6]
UNSPSC
12352211
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amxt-1501.html
Purity
99.44
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O
Molecular Formula
C32H68N6O2
Molecular Weight
568.92
References & Citations
[1]Hayes CS, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.|[2]Candace S Hayes, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
BioRxiv. 2024 Nov 17:2024.08.24.609500.|bioRxiv. 2025 January 26.|Cell Death Differ. 2024 Jul;31 (7) :910-923.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Nat Commun. 2024 Mar 19;15 (1) :2461.|Neuro Oncol. 2025 May 27:noaf128.|Research Square Preprint. 2024 Mar 19.|The University of Texas at San Antonio. 2025.
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