AMXT-1501
Product Specifications
UNSPSC Description
AMXT1501 is a novel inhibitor of the polyamine transport system. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amxt-1501.html
Purity
98.17
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O
Molecular Weight
568.92
References & Citations
[1]Hayes CS, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2(3):274-85.|[2]Candace S Hayes, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2(3):274-85.bioRxiv. 2024 August 26.|Cell Death Differ. 2024 Jun 10.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.|Nat Commun. 2024 Mar 19;15(1):2461.|Research Square Preprint. 2024 Mar 19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124617/AMXT-1501-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124617/AMXT-1501-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
441022-64-6
Available Sizes
Curated Selection
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