Pulixin

Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 μM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM[1].

Product Specifications

CAS Number

[2826264-81-5]

UNSPSC

12352005

Target

Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pulixin.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C=C(O)C=C2C3=C(O1)C=C(N)C=C3C

Molecular Formula

C14H11NO4

Molecular Weight

257.24

References & Citations

[1]Niu G, et al. A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection. Parasit Vectors. 2021;14 (1) :177. Published 2021 Mar 24.