Pulixin
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 μM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM[1].
Product Specifications
CAS Number
[2826264-81-5]
UNSPSC
12352005
Target
Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pulixin.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C(O)C=C2C3=C(O1)C=C(N)C=C3C
Molecular Formula
C14H11NO4
Molecular Weight
257.24
References & Citations
[1]Niu G, et al. A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection. Parasit Vectors. 2021;14 (1) :177. Published 2021 Mar 24.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Microbial Metabolite; Plasmodium
Curated Selection
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