Beta-NGF Recombinant Protein
Product Specifications
Background
β -NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β -NGF is a potent neurotrophic factor that signals through its receptor β -NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β -NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of Recombinant Human β -NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.
CAS Number
9000-83-3
NCBI Gene ID
4803
Swiss Prot
P01138
Accession Number
NP_002497.2
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Growth Factors, Neuroscience, Signal Transduction
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Beta-NGF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Beta-NGF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Beta-NGF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Nerve growth factor (beta polypeptide)
NCBI Organism
Homo sapiens
Other Product Names
NGFB, HSAN5, Beta-NGF, NGFB, Beta-nerve growth factor
Species
Human
Protein ID
70995319
Physical Properties
Lyophilized
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