ZBP1 Recombinant Protein
Product Specifications
Background
Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
NCBI Gene ID
81030
Swiss Prot
Q9H171
Accession Number
Q9H171
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Innate Immunity
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-262
Calculated Molecular Weight
17.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Z-DNA binding protein 1
NCBI Organism
Homo sapiens
Other Product Names
Z-DNA-Binding Protein 1, Tumor Stroma and Activated Macrophage Protein DLM, ZBP1, C20orf183, DLM1
Species
Human
Protein ID
530379522
Physical Properties
Lyophilized
CAS Number
9000-83-3
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