VTCN1 Recombinant Protein
Product Specifications
Background
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs) . VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
CAS Number
9000-83-3
NCBI Gene ID
79679
Swiss Prot
Q7Z7D3
Accession Number
NP_078902
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Innate Immunity
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH 7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
26.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
V-set domain containing T cell activation inhibitor 1
NCBI Organism
Homo sapiens
Background Reference 01
Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
Background Reference 02
Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
Background Reference 03
Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.
Other Product Names
B7-H4, VTCN1, B7S1, B7h.5
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Claudin-3 Antibody (OTI1E7) [DyLight 755]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)