VEGF R3 / FLT4 Recombinant Protein
Product Specifications
Background
Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs) . VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.
NCBI Gene ID
14257
Swiss Prot
P35917
Accession Number
NP_032055.1
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-492
Calculated Molecular Weight
111.5 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 116-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
FMS-like tyrosine kinase 4
NCBI Organism
Mus musculus
Background Reference 01
Stuttfeld E., et al., 2009, IUBMB Life, 61 (9) : 915-922.
Background Reference 02
Zygmunt T., et al., 2011, Dev Cell, 21 (2) : 301-314.
Background Reference 03
Herzog, B., et al., 2011, Molecular Biology of the Cell, 22 (15) : 2766-2776.
Other Product Names
Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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