PLAU Recombinant Protein
Product Specifications
Background
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction) .
NCBI Gene ID
5328
Swiss Prot
P00749
Accession Number
NP_002649.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Neuroscience, Obesity
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM NaAc, 100 mM NaCl, pH5.0
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-630
Calculated Molecular Weight
45 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Plasminogen activator, urokinase
NCBI Organism
Homo sapiens
Background Reference 01
Nagai M., et al., 1985, Gene 36:183.
Background Reference 02
Jacobs P., et al., 1985, DNA 4:139.
Background Reference 03
Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.
Other Product Names
Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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