PLAU / uPA Recombinant Protein
Product Specifications
Background
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction) .
Accession Number
NP_002649.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Neuroscience, Obesity
Purity
>90% as determined by SDS-PAGE.
Buffer
25 mM HEPES, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-306
Calculated Molecular Weight
15.3 kDa, 17.8 kDa and 29.2 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The long
Background Reference 01
Nagai M., et al., 1985, Gene 36:183.
Background Reference 02
Jacobs P., et al., 1985, DNA 4:139.
Background Reference 03
Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.
Other Product Names
Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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