UBE2K Recombinant Protein
Product Specifications
Background
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.
CAS Number
9000-83-3
NCBI Gene ID
3093
Swiss Prot
P61086
Accession Number
P61086
Tag
N-6 His, SUMO tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Neuroscience
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-174
Calculated Molecular Weight
34.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Ubiquitin conjugating enzyme E2 K
NCBI Organism
Homo sapiens
Other Product Names
Ubiquitin-Conjugating Enzyme E2 K, Huntingtin-Interacting Protein 2, HIP-2, Ubiquitin Carrier Protein, Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2 (25K), Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Protein Ligase, UBE2K, HIP2, LIG, E2-25K
Species
Human
Physical Properties
Liquid
Curated Selection
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