Death Receptor 6 Recombinant Protein
Product Specifications
Background
Tumor necrosis factor receptor superfamily member 21 (DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) . N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) .
NCBI Gene ID
94185
Swiss Prot
Q9EPU5
Accession Number
Q9EPU5
Tag
C-Fc-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-950
Calculated Molecular Weight
64.7 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 21
NCBI Organism
Mus musculus
Other Product Names
Tumor necrosis factor receptor superfamily member 21, Death receptor 6, Tnfrsf21, CD358, BM-018, DR6
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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