Osteoprotegerin Recombinant Protein
Product Specifications
Background
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG) . TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
CAS Number
9000-83-3
NCBI Gene ID
4982
Swiss Prot
O00300
Accession Number
NP_002537
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cell Cycle, Growth Factors, Immunology, Neuroscience, Obesity, Signal Transduction, Other
Purity
>92% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
70.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 11b
NCBI Organism
Homo sapiens
Background Reference 01
Tsuda E., et al, 1997, Biochem. Biophys. Res. Commun. 234:137-142.
Background Reference 02
Emery J.G., et al., 1998, J. Biol. Chem. 273:14363-14367.
Background Reference 03
Luan X., et al., 2012, J. Immunol. 189:245-252.
Other Product Names
TNFRSF11B, OCIF, OPG, Osteoprotegerin
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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