TRAIL R3 Recombinant Protein

Product Specifications

Background

Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

CAS Number

9000-83-3

NCBI Gene ID

8794

Swiss Prot

O14798

Accession Number

O14798

Tag

C-Fc-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Apoptosis, Cancer, Immunology

Buffer

Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

48.7 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Tumor necrosis factor receptor superfamily member 10c

NCBI Organism

Homo sapiens

Other Product Names

Tumor Necrosis Factor Receptor Superfamily Member 10C, Antagonist Decoy Receptor for TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Decoy Receptor 1, DcR1, Lymphocyte Inhibitor of TRAIL, TNF-Related Apoptosis-Inducing Ligand Receptor 3, TRAIL Receptor 3, TRAIL-R3, TRAIL Receptor Without an Intracellular Domain, CD263, TNFRSF10C, LIT, TRAILR3, TRID