TNFR1 Recombinant Protein
Product Specifications
Background
Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) .
CAS Number
9000-83-3
NCBI Gene ID
7132
Swiss Prot
P19438
Accession Number
NP_001056
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction, Other, Inflammasomes
Purity
>98% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
47.9 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 1A
NCBI Organism
Homo sapiens
Background Reference 01
Jiang Y., et al., 1999, Science 283:543-546.
Background Reference 02
Le V.T., et al., 2011, J. Virol. 85:13260-13270.
Background Reference 03
Gregory A.P., et al., 2012, Nature 488:508-511.
Other Product Names
TNFR1, CD120a, TNFRSF1A, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR55, TNFR60, p55, p60
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
