LIGHT / TNFSF14 Recombinant Protein
Product Specifications
Background
Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR) . LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
NCBI Gene ID
8740
Swiss Prot
O43557
Accession Number
NP 003798.2
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-456
Calculated Molecular Weight
45.1 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
TNF superfamily member 14
NCBI Organism
Homo sapiens
Background Reference 01
Mauri DN., et al. 1998, Immunity., 8, 21-30.
Background Reference 02
Granger SW., et al. 2003, Cytokine Growth Factor Rev., 14 (3-4), 289-96.
Background Reference 03
Pasero C., et al. 2009, Curr Mol Med., 9 (7), 911-27.
Other Product Names
CD258 antigen, CD258, HVEM-L, LIGHT, LTg, TNFSF14, TR2, HVEML
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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