TROP-2 / TACSTD2 Recombinant Protein
Product Specifications
Background
TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
NCBI Gene ID
56753
Swiss Prot
Q8BGV3
Accession Number
NP_064431.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Homeostasis, Immunology, Other
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-191
Calculated Molecular Weight
29.9 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.9 kDa. The protein migrates as 38-48 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
NCBI Official Name
Tumor-associatedcalciumsignaltransducer2
NCBI Organism
Mus musculus
Background Reference 01
Simms A., et al., 2016, Diagn. Cytopathol. 44:26-31.
Background Reference 02
Fornaro M., et al., 1995, Int. J. Cancer. 62 (5) :610-618.
Other Product Names
TACSTD2, GA733-1, M1S1, TROP2
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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