Osteoactivin Recombinant Protein
Product Specifications
Background
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
CAS Number
9000-83-3
NCBI Gene ID
10457
Swiss Prot
Q14956
Accession Number
AAH32783
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
52.9 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Glycoprotein (transmembrane) nmb
NCBI Organism
Homo sapiens
Background Reference 01
Weterman MA., et al., 1995, International Journal of Cancer 60 : 73–81.
Background Reference 02
Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13) : 2334–51.
Background Reference 03
Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1) : 26–37.
Other Product Names
GPNMB, HGFIN, NMB, Osteoactivin
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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