TGF beta RII Recombinant Protein
Product Specifications
Background
Transforming growth factor- beta (TGF- beta) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF- beta regulates cellular processes by binding to three high-affinity cell surface receptors: TGF- beta receptor type I (TGF- beta -RI), TGF- beta receptor type II (TGF- beta -RII), and TGF- beta beta receptor type III (TGF- beta -RIII) . TGF- beta RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF- beta) receptor subfamily. TGF- beta RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
NCBI Gene ID
21813
Swiss Prot
Q62312-2
Accession Number
Q62312-2
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-597
Calculated Molecular Weight
42.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Transforming growth factor, beta receptor II
NCBI Organism
Mus musculus
Other Product Names
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, Tgfbr2
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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