TRAIL-R2 Recombinant Protein
Product Specifications
Background
TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
CAS Number
9000-83-3
NCBI Gene ID
8795
Swiss Prot
P25445
Accession Number
O14763
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Homeostasis, Immunology, Other
Concentration
1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 50 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10b
NCBI Organism
Homo sapiens
Other Product Names
DR5, TNFRSF 10B, CD262, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRAIL Receptor 2
Species
Human, Mouse
Protein ID
2338419
Physical Properties
Lyophilized
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