KillerTRAIL, Soluble Recombinant Protein
Product Specifications
Background
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B) . Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC) .
CAS Number
9000-83-3
NCBI Gene ID
8743
Swiss Prot
P13500
Accession Number
P50591
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer, Growth Factors, Immunology
Concentration
0.5 mg/ml
Buffer
In 20mM HEPES, pH 7.4, 150mM NaCl, 0.005% Tween 20, 1% sucrose, 1mM DTT.
Shipping Conditions
Dry Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -80˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 10
NCBI Organism
Homo sapiens
Other Product Names
TRAIL, Apo-2L, TNFSF10, CD253
Species
Human, Mouse
Protein ID
4507593
Physical Properties
Liquid
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