TNF-alpha Recombinant Protein
Product Specifications
Background
TNF-a is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-a is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-a also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-a is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
NCBI Gene ID
7124
Swiss Prot
P01375
Accession Number
NP_000585.2
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Obesity, Signal Transduction
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized TNF-alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TNF-alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TNF-alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=40-609
NCBI Official Name
Tumor necrosis factor
NCBI Organism
Homo sapiens
Other Product Names
DIF, TNFA, TNFSF2, TNF-alpha, Tumor necrosis factor, Cachectin, TNF-a
Species
Human
Protein ID
25952111
Physical Properties
Lyophilized
CAS Number
9000-83-3
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