TFPI2 Recombinant Protein
Product Specifications
Background
Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI) . TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.
NCBI Gene ID
7980
Swiss Prot
P48307
Accession Number
NP_006519.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-712
Calculated Molecular Weight
22.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Tissue factor pathway inhibitor 2
NCBI Organism
Homo sapiens
Background Reference 01
Rao C.N., et al., 1995, Arch. Biochem. Biophys. 317:311-314.
Background Reference 02
Tanaka Y., et al., 2004, Invest. Ophthalmol. Vis. Sci. 45:245.
Background Reference 03
Rollin J., et al., 2005, Br, J. Cancer 92:775.
Other Product Names
TFPI2, PP5, REF1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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