Tie-1 Recombinant Protein
Product Specifications
Background
TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) ], but no ligand was found for TIE-1.
NCBI Gene ID
7075
Swiss Prot
P35590
Accession Number
P35590
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM MES, 150mM NaCl, pH 5.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-454
Calculated Molecular Weight
81 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Tyrosine kinase with immunoglobulin like and EGF like domains 1
NCBI Organism
Homo sapiens
Other Product Names
Tyrosine-Protein Kinase Receptor Tie-1, TIE1, TIE
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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