TSLP (R127A, R130S) Recombinant Protein
Product Specifications
Background
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5) . Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
NCBI Gene ID
102119254
Accession Number
XP_005557555.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-260
Calculated Molecular Weight
16.9 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. The protein migrates as 23-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Thymic stromal lymphopoietin
NCBI Organism
Macaca fascicularis
Background Reference 01
Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015.
Background Reference 02
Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
Background Reference 03
Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.
Other Product Names
TSLP
Tested Applications
ELISA, WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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