TSLP Recombinant Protein
Product Specifications
Background
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5) . Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
NCBI Gene ID
102119254
Accession Number
XP_005557555.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-234
Calculated Molecular Weight
11.7 kDa and 5.4 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin convertase cleavage site, 127-RRKR-130, and will be processed into N and C-terminal fragment with calculated MW of 11.7 kDa and 5.4 kDa respectively. The protein mig
NCBI Official Name
Thymicstromallymphopoietin
NCBI Organism
Macaca fascicularis
Background Reference 01
Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015.
Background Reference 02
Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
Background Reference 03
Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.
Other Product Names
TSLP
Tested Applications
ELISA, WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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