TGF-Beta3 Recombinant Protein

The three mammalian isoforms of TGF-β , TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Manufactured using all non-animal reagents.

The lyophilized TGF-Beta3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TGF-Beta3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TGF-Beta3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.