Siglec-10 Recombinant Protein
Product Specifications
Background
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
NCBI Gene ID
89790
Swiss Prot
Q96LC7
Accession Number
NP_149121.2
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-411
Calculated Molecular Weight
85.6 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 85.6 kDa. The protein migrates as 90-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Sialic acid binding Ig like lectin 10
NCBI Organism
Homo sapiens
Background Reference 01
Whitney G., et al. 2001, Eur J Biochem., 268 (23), 6083-96.
Background Reference 02
Kivi E., et al. 2009, Blood., 114 (26), 5385-92.
Background Reference 03
Munday J., et al. 2001, Biochem J., 355 (Pt 2), 489-97.
Other Product Names
SIGLEC10, MGC126774, PRO940, Siglec10, SLG2
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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