Angiopoietin-like protein 8 Recombinant Protein
Product Specifications
Background
The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.
NCBI Gene ID
55908
Swiss Prot
Q6UXH0
Accession Number
Q6UXH0
Tag
N-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Obesity
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-639
Calculated Molecular Weight
48 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Angiopoietin like 8
NCBI Organism
Homo sapiens
Other Product Names
Betatrophin, Angiopoietin-like protein 8, Lipasin, Angptl8
Species
Human
Protein ID
291219911
Physical Properties
Lyophilized
CAS Number
9000-83-3
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