IL-1 Rrp2 / IL-1 R6 Recombinant Protein
Product Specifications
Background
The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9) . All family members possess three immunoglobulin (Ig) -like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.
Accession Number
EHH61702.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Chemokines & Cytokines, Immunology, Infectious Disease, Neuroscience, Signal Transduction, Stem Cell
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-170
Calculated Molecular Weight
37.9 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.9 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Background Reference 01
Boraschi D., et al. 2013, Semin Immunol., 25 (6), 394-407.
Background Reference 02
Lovenberg TW., et al. 2013, Semin Immunol., 25 (6), 394-407.
Background Reference 03
Debets R., et al. 2001, J Immunol., 167 (3), 1440-6.
Other Product Names
IL-1 R6, IL-1 Rrp2, IL1RL2, IL-1RL2, IL1Rrp2, IL-1Rrp2, IL1RRP2, IL-36R
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
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