EGF R Recombinant Protein
Product Specifications
Background
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4) . Mutations affecting EGFR expression or activity could result in cancer.
CAS Number
9000-83-3
Accession Number
NP_005219.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
70.5kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.5kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Herbst RS., 2004, Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl) : 21–6.
Background Reference 02
Giaccone, G., 2005, Ann. Onc. 16: 538-548.
Other Product Names
EGFR, ERBB, ERBB1, HER1, PIG61, mENA
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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