Rhesus macaque CD28 Recombinant Protein
Product Specifications
Background
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) . When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs) . The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
CAS Number
9000-83-3
NCBI Gene ID
940
Swiss Prot
P10747
Accession Number
NP_006130.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Homeostasis, Immunology, Obesity, Signal Transduction, Stem Cell
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-435
Calculated Molecular Weight
41.6 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.6 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD28 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Evans E.J., et al., 2005, Nat. Immunol. 6:271-279.
Background Reference 02
Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46.
Background Reference 03
Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
Other Product Names
CD28, Tp44
Tested Applications
ELISA, WB
Species
Human, Cynomolgus, Rhesus macaque
Physical Properties
Lyophilized
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