CD5 Recombinant Protein
Product Specifications
Background
T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1, which is phosphorylated on tyrosine residues by LYN, so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
CAS Number
9000-83-3
NCBI Gene ID
921
Swiss Prot
P06127
Accession Number
NP_055022
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
40.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD5 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Van de Velde H., et al., 1991, Nature 351:662-665.
Background Reference 02
Brill L.M., et al., 2004, Anal. Chem. 76:2763-2772.
Background Reference 03
Rodamilans B., et al., 2007, J. Biol. Chem. 282:12669-12677.
Other Product Names
CD5, LEU1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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