CD4 Recombinant Protein
Product Specifications
Background
T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Swiss Prot
G7N5T8
Accession Number
G7N5T8
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-106
Calculated Molecular Weight
42.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
Background Reference 01
Brady RL, et al., 1993, Science 260 (5110) : 979–83.
Background Reference 02
Zeitlmann, L., et al., 2001, J. Biol. Chem. (United States) 276 (12) : 9123–32.
Background Reference 03
Rudd CE, et al., 2010, J. Immunol. 185 (5) : 2645–9.
Background Reference 04
Rudd CE, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (14) : 5190–4.
Other Product Names
CD4, CD4mut, LEU3
Tested Applications
WB
Species
Rhesus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
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