CD3 epsilon Recombinant Protein
Product Specifications
Background
T-Cell Surface Glycoprotein CD3 epsilon Chain (CD3 epsilon) is a single-pass type I membrane protein. CD3 epsilon contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3 epsilon is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) . TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
NCBI Gene ID
916
Swiss Prot
P07766
Accession Number
P07766
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-516
Calculated Molecular Weight
12.79 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD3e molecule
NCBI Organism
Homo sapiens
Other Product Names
T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3e, T3E
Species
Human
Protein ID
767983919
Physical Properties
Lyophilized
CAS Number
9000-83-3
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